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KMID : 0363620080290020032
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Journal of Korean Oriental Medicine
2008 Volume.29 No. 2 p.32 ~ p.40
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Analgesic and anti-inflammatory effect of the aqueous extract of Angelica dahurica
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Choi In-Ho
Song Yun-Kyung
Lim Hyung-Ho
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Abstract
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Background: Angelica dahurica has been used in various clinical cases. Its taste is hot and its property is warm, dry and nonpoisonous. Its efficacy is to remove wind-damp, cure swelling and edema, exhaust pus, stop itching, rhinitis
and leukorrhea.
Object: To test through experiment Angelica dahurica’s analgesic and anti-inflammatory efficacy.
Method: Inject acetic acid as a pain-inducing substance to the mice and measure visceral pain bywrithing reflex. Inject carrageenan that is an edema-inducing substance to the rat’s paw and measure volume of edema. Take thermal pain to mice with plantar test and measure paw withdrawal latency. Normal group is non Angelica dahurica-treated group
and treated group is Angelica dahurica-treated group.
Results: In acetic acid-induced visceral model, treatment with Angelica dahurica suppressed writhing reflex significantlyand dose-dependently. In carrageenan-induced paw edema model, treatment with Angelica dahurica suppressed carrageenan-induced paw edema. In plantar test model, no significant effect on the withdrawal latency of thermal stimulation-induced nociception was observed.
Conclusion: Angelica dahurica has analgesic and anti-inflammatory efficacy.
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KEYWORD
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Angelica dahurica, analgesic, edema, carrageenan edema, writhing reflex, the plantar test
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